(E/Z) -Dacinostat

(E/Z) -Dacinostat ((E/Z) -NVP-LAQ824) is a histone deacetylase inhibitor that has the ability to induce apoptosis and enhance the activity of fludarabine in killing leukemia cells. (E/Z) -Dacinostat can trigger the production of reactive oxygen species (ROS) and DNA damage, enhance the killing effect of fludarabine on leukemia cells, and induce apoptosis. Its mechanism is related to the regulation of DNA repair processes and intracellular signaling pathways.

Product Specifications

CAS Number

[591207-53-3]

Product Name Alternative

(E/Z) -NVP-LAQ824; (E/Z) -LAQ824

UNSPSC

12352005

Target

Apoptosis; HDAC

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/e-z-dacinostat.html

Smiles

O=C(/C=C/C1=CC=C(C=C1)CN(CCC2=CC3=C(C=CC=C3)N2)CCO)NO

Molecular Formula

C22H25N3O3

Molecular Weight

379.45

References & Citations

[1]Strategy for enhancing the therapeutic efficacy of histone deacetylase inhibitor dacinostat: the novel paradigm to tackle monotonous cancer chemoresistance