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Cimetidine (hydrochloride) (Standard)

Cimetidine (hydrochloride) (Standard) is the analytical standard of Cimetidine (hydrochloride) . This product is intended for research and analytical applications. Cimetidine (SKF-92334) hydrochloride is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine hydrochloride is a gastric acid reducer, and can be used for duodenal and gastric ulcers research. Cimetidine hydrochloride has anti-cancer and anti-inflammatory activity[1][2][5].

Product Specifications

CAS Number

[70059-30-2]

Product Name Alternative

SKF-92334 (hydrochloride) (Standard)

UNSPSC

12352005

Target

Bacterial; Histamine Receptor; Reference Standards

Type

Reference compound

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/cimetidine-hydrochloride-standard.html

Smiles

CC1=C(CSCC/N=C(NC)/NC#N)NC=N1.[H]Cl

Molecular Formula

C10H17ClN6S

Molecular Weight

288.80

References & Citations

[1]M J Smit, et al. Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors. Proc Natl Acad Sci U S A. 1996 Jun 25;93 (13) :6802-7.|[2]Takahashi, H.K., et al., Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes. Mol Pharmacol, 2006. 70 (2) : p. 450-3.|[3]Sprowl, J.A., et al., Conjunctive therapy of cisplatin with the OCT2 inhibitor cimetidine: influence on antitumor efficacy and systemic clearance. Clin Pharmacol Ther, 2013. 94 (5) : p. 585-92.|[4]Zheng, Y., et al., Cimetidine suppresses lung tumor growth in mice through proapoptosis of myeloid-derived suppressor cells. Mol Immunol, 2013. 54 (1) : p. 74-83.|[5]Fukuda, M., K. Kusama, and H. Sakashita, Cimetidine inhibits salivary gland tumor cell adhesion to neural cells and induces apoptosis by blocking NCAM expression. BMC Cancer, 2008. 8: p. 376.|[6]Longhini, R., et al., Cimetidine Reduces the Alveolar Bone Loss in Induced Periodontitis in Rat Molars. J Periodontol, 2013.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

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