EEDQ

EEDQ is a carboxylate activator and irreversible antagonist of 5HT2c receptors. EEDQ reduces [3H]β-CIT binding to the dopamine transporter (DAT) in rat caudate-putamen (CPu) homogenates (IC50 = 78.3 μM) . EEDQ inhibits contralateral rotation behavior[1][2][3][4][5].

Product Specifications

CAS Number

[16357-59-8]

Product Name Alternative

EEDQ

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor; Biochemical Assay Reagents; Dopamine Transporter

Type

Biochemical Assay Reagents

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/eedq.html

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N1C(OCC)C=CC2=C1C=CC=C2)OCC

Molecular Formula

C14H17NO3

Molecular Weight

247.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Hughes B P, et al. Effects of N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) on agonist-stimulated Ca2+ inflow across the hepatocyte plasma membrane. Biochemical pharmacology, 1991, 41 (6-7) : 1087-1090. |[2]Ni YG, et al. Irreversible antagonism of 5HT2c receptors by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) . Proc Natl Acad Sci U S A. 1997 Mar 18;94 (6) :2715-8. |[3]Tarazi FI, et al. Alkylation of rat dopamine transporters and blockade of dopamine uptake by EEDQ. Neuropharmacology. 2000 Aug 23;39 (11) :2133-8. |[4]Goodale DB, et al. Selective protection from the inhibition by EEDQ of D1 and D2 dopamine agonist-induced rotational behavior in mice. Pharmacol Biochem Behav. 1988 Jun;30 (2) :457-62.|[5]Mestlin M, et al. Ontogenetic differences in the effects of EEDQ on dopamine-mediated behaviors. Pharmacol Biochem Behav. 1993 Aug;45 (4) :797-802.