ZINC110492
ZINC110492 is a selective ligand of CS-ΔEx4 (a splicing isoform of citrate synthase (CS) ) . ZINC110492 does not bind to CS full-length (CS-FL) . ZINC110492 inhibits colorectal cancer (CRC) cell growth in cells overexpressing CS-ΔEx4 with an IC50 of 7.840 µM. ZINC110492 significantly decreases both citrate and 2-hydroxyglutarate (2-HG) levels in the CS-ΔEx4-overexpressing SW1116 cells[1].
Product Specifications
CAS Number
[100264-64-0]
UNSPSC
12352005
Target
Biochemical Assay Reagents
Type
Reference compound
Related Pathways
Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/6-3-nitrophenyl-5h-dibenzo-c-e-azepine-5-7-6h-dione.html
Purity
90.0
Smiles
O=C1C2=C(C3=C(C(N1C4=CC([N+]([O-])=O)=CC=C4)=O)C=CC=C3)C=CC=C2
Molecular Formula
C20H12N2O4
Molecular Weight
344.32
References & Citations
[1]Cheung JCT, et al. A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression. Cancer Res. 2025 Sep 3.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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