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Tazemetostat de (methylene morpholine) -O-C3-O-C-COOH

Tazemetostat de (methylene morpholine) -O-C3-O-C-COOH (Compound 21b) incorporates a ligand for EZH2, and a PROTAC linker, which recruit E3 ligases. Tazemetostat de (methylene morpholine) -O-C3-O-C-COOH (Compound 21b) can be used for the research of lymphoma[1].

Product Specifications

CAS Number

[2750350-39-9]

UNSPSC

12352005

Target

Histone Methyltransferase; Target Protein Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tazemetostat-de-methylene-morpholine-o-c3-o-c-cooh.html

Purity

99.06

Solubility

DMSO : ≥ 160 mg/mL

Smiles

O=C(COCCCOC1=CC=C(C2=CC(C(NCC3=C(C)C=C(C)NC3=O)=O)=C(C)C(N(C4CCOCC4)CC)=C2)C=C1)O

Molecular Formula

C34H43N3O7

Molecular Weight

605.72

References & Citations

[1]Tu Y, et al. Design, Synthesis, and Evaluation of VHL-Based EZH2 Degraders to Enhance Therapeutic Activity against Lymphoma. J Med Chem. 2021 Jul 22;64 (14) :10167-10184.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

EZH2

Available Sizes

Curated Selection

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