Human CUL1 Protein

<strong>Human CUL1 Protein</strong>_x000D_ <strong>Catalog number:</strong> B2012078_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 50 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 1 mg/mL_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20 °C_x000D_ <strong>Keywords:</strong> CUL-1 protein, CUL 1 protein, CUL 1, CUL1, Cullin-1 protein, MGC149834 protein, MGC149835, CUL-1 protein, CUL-1, Cullin-1 protein_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Liu A. Proteostasis in the Hedgehog signaling pathway Semin Cell Dev Biol. 2019 Sep;93:153-163._x000D_ 2: Dang F, Nie L, Wei W. Ubiquitin signaling in cell cycle control and tumorigenesis Cell Death Differ. 2021 Feb;28(2):427-438._x000D_ 3: Nguyen KM, Busino L. The Biology of F-box Proteins: The SCF Family of E3 Ubiquitin Ligases Adv Exp Med Biol. 2020;1217:111-122._x000D_ 4: Horn-Ghetko D, Krist DT, Prabu JR, Baek K, Mulder MPC, Klügel M, Scott DC, Ovaa H, Kleiger G, Schulman BA. Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly Nature. 2021 Feb;590(7847):671-676._x000D_ 5: Zheng N, Schulman BA, Song L, Miller JJ, Jeffrey PD, Wang P, Chu C, Koepp DM, Elledge SJ, Pagano M, Conaway RC, Conaway JW, Harper JW, Pavletich NP. Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex Nature. 2002 Apr 18;416(6882):703-9._x000D_ 6: Xie CM, Wei W, Sun Y. Role of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases in skin cancer J Genet Genomics. 2013 Mar 20;40(3):97-106._x000D_ 7: Kostrhon S, Prabu JR, Baek K, Horn-Ghetko D, von Gronau S, Klügel M, Basquin J, Alpi AF, Schulman BA. CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation Nat Chem Biol. 2021 Oct;17(10):1075-1083._x000D_ 8: Cui D, Xiong X, Shu J, Dai X, Sun Y, Zhao Y. FBXW7 Confers Radiation Survival by Targeting p53 for Degradation Cell Rep. 2020 Jan 14;30(2):497-509.e4._x000D_ 9: Harper JW, Schulman BA. Cullin-RING Ubiquitin Ligase Regulatory Circuits: A Quarter Century Beyond the F-Box Hypothesis Annu Rev Biochem. 2021 Jun 20;90:403-429._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/34644148">10: Bellail AC, Jin HR, Lo HY, Jung SH, Hamdouchi C, Kim D, Higgins RK, Blanck M, le Sage C, Cross BCS, Li J, Mosley AL, Wijeratne AB, Jiang W, Ghosh M, Zhao YQ, Hauck PM, Shekhar A, Hao C. Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors Sci Transl Med. 2021 Oct 13;13(615):eabh1486. </a>_x000D_ _x000D_ <strong>Products Related to Human CUL1 Protein can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>