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N.41

N.41 is an antiviral agent. N.41 protects APOBEC3G (an antiviral factor) from HIV Vif protein-mediated degradation. N.41 inhibits the Vif-A3G interaction and increases cellular A3G levels and incorporation of A3G into virions, thereby attenuating virus infectivity in a Vif-dependent manner. N.41 inhibits HIV-1 viral replication in PBMCs (IC50: 8.4 μM) [1].

Product Specifications

CAS Number

357441-99-7

UNSPSC

12352005

Target

HIV

Type

Reference compound

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/n-41.html

Smiles

C/C(NC1=CC=C(O)C=C1)=C\C(C2=CC=CN=C2)=O

Molecular Formula

C15H14N2O2

Molecular Weight

254.28

References & Citations

[1]Pery E, et al. Identification of a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G protein. J Biol Chem. 2015 Apr 17;290 (16) :10504-17.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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