KOTX1
KOTX1 is an orally active and selective ALDH1A3 inhibitor. KOTX1 improves glucose tolerance, insulin secretion and blood sugar levels in diabetic mouse models[1].
Product Specifications
CAS Number
1788963-83-6
Product Name Alternative
MBE1
UNSPSC
12352005
Target
Aldehyde Dehydrogenase (ALDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/kotx1.html
Purity
98.94
Solubility
DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(C1=C(CC)C=NC=C1)NC2=C(F)C=C(NC(CC3)=O)C3=C2
Molecular Formula
C17H16FN3O2
Molecular Weight
313.33
References & Citations
[1]Son J, et al. Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure. Nat Commun. 2023 Feb 2;14 (1) :558.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ALDH1
Available Sizes
Frequently Asked Questions
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