IN-RNA-IN-2

IN-RNA-IN-2 (compound 1a) is an inhibitor (IC50=70 nM) of the interaction between HIV-1 integrase and the viral RNA genome. IN-RNA-IN-2 exerts its anti-HIV activity by inhibiting the viral replication process[1].

Product Specifications

UNSPSC

12352005

Target

HIV; HIV Integrase

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/in-rna-in-2.html

Smiles

O=C(O)C(/C(O)=C/C(C1=CN(CC2=CC=C(F)C=C2)C3=C(C=C(C(/C=C(C(O)=O)\O)=O)C=C3)C1=O)=O)=O

Molecular Formula

C25H16FNO10

Molecular Weight

509.39

References & Citations

[1]Patacchini, et al. "Quinolinonyl Derivatives as Dual Inhibitors of the HIV-1 Integrase Catalytic Site and Integrase–RNA interactions." ACS Medicinal Chemistry Letters (2024) .