2-Methylthioadenosine

2-Methylthioadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Product Specifications

CAS Number

[4105-39-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2-methylthioadenosine.html

Purity

98.82

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

NC1=C2N=CN([C@H]3[C@@H](O)[C@@H](O)[C@@H](CO)O3)C2=NC(SC)=N1

Molecular Formula

C11H15N5O4S

Molecular Weight

313.33

Precautions

H302, H315, H319, H335

References & Citations

[1]Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26 (6) :1490-1500.|[2]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.