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Olomoucine II

Olomoucine II is a potent CDK inhibitor with IC50 values of 0.06, 0.1, 0.45, 7.6, 19.8 µM for CDK9/cyclin T, CDK2/cyclin E, CDK7/cyclin H, CDK1/cyclin B, CDK4/cyclin D1, respectively. Olomoucine II shows antiproliferative activity[1].

Product Specifications

CAS Number

[500735-47-7]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/olomoucine-ii.html

Smiles

OC1=CC=CC=C1CNC2=C3N=CN(C(C)C)C3=NC(N[C@@H](CO)CC)=N2

Molecular Formula

C19H26N6O2

Molecular Weight

370.45

Precautions

P264-P270-P280-P302+P352-P330-P362+P364-P501

References & Citations

[1]Krystof V, et al. Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor. Cell Mol Life Sci. 2005 Aug;62 (15) :1763-71.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK1; CDK2; CDK4; CDK7; CDK9

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