(S) -ACE-OH
(S) -ACE-OH is a molecular glue with anticancer activity. (S) -ACE-OH promotes nucleoporin degradation and disruption of nucleocytoplasmic trafficking by inducing the interaction between E3 ubiquitin ligase TRIM21 and nucleoporin NUP98[1].
Product Specifications
UNSPSC
12352005
Target
Molecular Glues
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-ace-oh.html
Purity
99.17
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@H](C1=CC2=C(SC3=C(N2CCCN(C)C)C=CC=C3)C=C1)O
Molecular Formula
C19H24N2OS
Molecular Weight
328.47
References & Citations
[1]Lu P, et al. Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders[J]. Cell, 2024.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TRC-L472900-25MG 25 mg
Loxoprofen Sodium (Mixture of diastereomers)
Sign In for Pricing
View Details 
BNC680487-100 1x 100 µL
ODC-1 (Ornithine Decarboxylase-1) (ODC1/487), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 