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(S) -ACE-OH

(S) -ACE-OH is a molecular glue with anticancer activity. (S) -ACE-OH promotes nucleoporin degradation and disruption of nucleocytoplasmic trafficking by inducing the interaction between E3 ubiquitin ligase TRIM21 and nucleoporin NUP98[1].

Product Specifications

UNSPSC

12352005

Target

Molecular Glues

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/s-ace-oh.html

Purity

99.17

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@H](C1=CC2=C(SC3=C(N2CCCN(C)C)C=CC=C3)C=C1)O

Molecular Formula

C19H24N2OS

Molecular Weight

328.47

References & Citations

[1]Lu P, et al. Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders[J]. Cell, 2024.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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