(S) -ACE-OH
(S) -ACE-OH is a molecular glue with anticancer activity. (S) -ACE-OH promotes nucleoporin degradation and disruption of nucleocytoplasmic trafficking by inducing the interaction between E3 ubiquitin ligase TRIM21 and nucleoporin NUP98[1].
Product Specifications
UNSPSC
12352005
Target
Molecular Glues
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-ace-oh.html
Purity
99.17
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@H](C1=CC2=C(SC3=C(N2CCCN(C)C)C=CC=C3)C=C1)O
Molecular Formula
C19H24N2OS
Molecular Weight
328.47
References & Citations
[1]Lu P, et al. Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders[J]. Cell, 2024.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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