Nitroxoline

Nitroxoline (8-Hydroxy-5-nitroquinoline), an antibiotic, is an orally active antibiofilm agent. Nitroxoline reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Nitroxoline can be used for the urinary tract infections and cancer research[1][2][3].

Product Specifications

CAS Number

[4008-48-4]

Product Name Alternative

8-Hydroxy-5-nitroquinoline; 5-Nitro-8-quinolinol

UNSPSC

12352005

Hazard Statement

H301+H311+H331, H315, H319, H335

Target

Antibiotic; Apoptosis; Autophagy; Bacterial

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Autophagy

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/Nitroxoline.html

Concentration

10mM

Purity

99.90

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1=C2N=CC=CC2=C([N+]([O-])=O)C=C1

Molecular Formula

C9H6N2O3

Molecular Weight

190.16

Precautions

H301+H311+H331, H315, H319, H335

References & Citations

[1]Jin-Guo Yu, et al. Nitroxoline induces cell apoptosis by inducing MDM2 degradation in small-cell lung cancer. Kaohsiung J Med Sci. 2019 Apr;35 (4) :202-208. |[2]A Sobke, et al. The urinary antibiotic 5-nitro-8-hydroxyquinoline (Nitroxoline) reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Antimicrob Agents Chemother. 2012 Nov;56 (11) :6021-5.