SMND-309
SMND-309 is a metabolite of salvianolic acid B, and exhibits neuroprotective effects in cultured neurons and in permanent middle cerebral artery occlusion rats[1][2].
Product Specifications
CAS Number
1065559-56-9
UNSPSC
12352005
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/SMND-309.html
Purity
97.12
Solubility
DMSO : ≥ 3.7 mg/mL
Smiles
OC1=C(C(/C=C/C(O)=O)=CC=C1O)/C(C(O)=O)=C\C2=CC(O)=C(C=C2)O
Molecular Formula
C18H14O8
Molecular Weight
358.30
References & Citations
[1]Hou J, Tian J, Jiang W, Gao Y, Fu F.
 Therapeutic effects of SMND-309, a new metabolite of salvianolic acid B, on experimental liver fibrosis.
 Eur J Pharmacol. 2011 Jan 10;650 (1) :390-5.|[2]Yang J, Zhang G, Tian J, Li C, Jiang W, Xing Y, Zhu H, Hou J, Xu H, Wu J.
 Cardioprotective effect of SMND-309, a novel derivate of salvianolic acid B on acute myocardial infarction in rats.
 Basic Clin Pharmacol Toxicol. 2010 Apr;106 (4) :317-23.|[3]Wang Y, Zhang J, Han M, et al. SMND-309 promotes neuron survival through the activation of the PI3K/Akt/CREB-signalling pathway. Pharm Biol. 2016;54 (10) :1982-1990.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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