Antileishmanial agent-28

Antileishmanial agent-28 (Compd 12) is an antileishmanial agent, with EC50 values of 1.5 μM (L.donovani), 13 μM (L.amazonensis) and 18 μM (J774A.1), respectively[1].

Product Specifications

CAS Number

[1135272-09-1]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/antileishmanial-agent-28.html

Solubility

10 mM in DMSO

Smiles

CNC1=NC(NCC2=CC=CC=C2)=C3C=CC=CC3=N1.Cl

Molecular Formula

C16H17ClN4

Molecular Weight

300.79

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

References & Citations

[1]Kurt S Van Horn, et al. Antileishmanial activity of a series of N², N⁴-disubstituted quinazoline-2,4-diamines. J Med Chem. 2014 Jun 26;57 (12) :5141-56.