PARP7-IN-16 (free base)
PARP7-IN-16 free base is the free base form of PARP7-IN-16. PARP7-IN-16 free base is a selective and orally active inhibitor of PARP-1/2/7, with IC50s of 0.94, 0.87 and 0.21 nM, respectively. PARP7-IN-16 can be used for the research of breast cancer and prostate cancer[1].
Product Specifications
CAS Number
2136325-05-6
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/parp7-in-16-free-base.html
Concentration
10mM
Purity
99.98
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=O)C2=CC=CC=C2N1CC3=CC=C(C(C(N4CCN(C(C4)=O)C(CC)CC)=O)=C3)F
Molecular Formula
C25H27FN4O4
Molecular Weight
466.50
References & Citations
[1]Zhou J, et, al. Discovery of Quinazoline-2,4 (1 H,3 H) -dione Derivatives Containing a Piperizinone Moiety as Potent PARP-1/2 Inhibitors─Design, Synthesis, In Vivo Antitumor Activity, and X-ray Crystal Structure Analysis. J Med Chem. 2023 Oct 26;66 (20) :14095-14115.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1; PARP2; PARP7
Available Sizes
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