PARP7-IN-16 (free base)

PARP7-IN-16 free base is the free base form of PARP7-IN-16 (HY-156419) . PARP7-IN-16 free base is a selective and orally active inhibitor of PARP-1/2/7, with IC50s of 0.94, 0.87 and 0.21 nM, respectively. PARP7-IN-16 can be used for the research of breast cancer and prostate cancer[1].

Product Specifications

CAS Number

[2136325-05-6]

UNSPSC

12352005

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/parp7-in-16-free-base.html

Concentration

10mM

Purity

99.98

Solubility

DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC1=O)C2=CC=CC=C2N1CC3=CC=C(C(C(N4CCN(C(C4)=O)C(CC)CC)=O)=C3)F

Molecular Formula

C25H27FN4O4

Molecular Weight

466.50

References & Citations

[1]Zhou J, et, al. Discovery of Quinazoline-2,4 (1 H,3 H) -dione Derivatives Containing a Piperizinone Moiety as Potent PARP-1/2 Inhibitors─Design, Synthesis, In Vivo Antitumor Activity, and X-ray Crystal Structure Analysis. J Med Chem. 2023 Oct 26;66 (20) :14095-14115.