SHH (C2) Antibody, Rabbit Polyclonal
Rabbit polyclonal to SHH.Sonic hedgehog (SHH) protein is instrumental in the development of all known animals. In theembryo, it is the key signal in patterning of the ventral neural tube, the anterior-posterior limb axis, andthe ventral somites. In the adult it controls stem cell proliferation. It binds to the patched (PTC) receptor, which functions in association with smoothened (SMO) to activate the transcription of genes.Disruption in SHH signaling during development either through defects in the protein, or maternalteratogen consumption can lead to developmental disorders such as holoprosencephaly (HPE) .Abberant activation of the SHH signaling pathway is associated with several types of cancer.
Product Specifications
Product Name Alternative
UniProt
Q15465
Reactivity
Human, Mouse
Immunogen
C-terminal region of human SHH
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Cell Biology
Dilution
WB:1:1000-1:5000
Purity
Affinity purification
Molecular Weight
50
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3
Frequently Asked Questions
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