7-Methoxytacrine

7-Methoxytacrine (7-MEOTA) is an inhibitor of human acetylcholinesterase (hAChE) with an IC50 value of 10 μM, and can be used for the research of Alzheimer's disease (AD) [1].

Product Specifications

CAS Number

[5778-80-3]

Product Name Alternative

7-MEOTA

UNSPSC

12352005

Hazard Statement

H301-H311-H315-H319-H331-H335-H351

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/7-methoxytacrine.html

Solubility

10 mM in DMSO

Smiles

NC1=C(CCCC2)C2=NC3=CC=C(OC)C=C31

Molecular Formula

C14H16N2O

Molecular Weight

228.29

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P361-P403+P233-P405-P501

References & Citations

[1]Spilovska K, et al. 7-Methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors in Alzheimer's disease treatment--synthesis, biological evaluation and molecular modeling studies. Molecules. 2013;18 (2) :2397-2418. Published 2013 Feb 20.