PTPN2/1-IN-3
PTPN2/1-IN-3 (compound 4) is a modified, orally active PTPN2/N1 inhibitor based on ABBV-CLS-484 (HY-145923) . PTPN2/1-IN-3 has anti-tumor effects, inhibiting PTPN2 with an IC50 of 9.3 nM and having an oral bioavailability of 93% in mice[1].
Product Specifications
UNSPSC
12352005
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ptpn2-1-in-3.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=C(N2CC(NS2(=O)=O)=O)C(O)=CC3=C1CCN(CC)CC3
Molecular Formula
C14H18FN3O4S
Molecular Weight
343.37
References & Citations
[1]Zheng J, et al. Synthesis and structure-activity optimization of azepane-containing derivatives as PTPN2/PTPN1 inhibitors. Eur J Med Chem. 2024 Apr 15;270:116390.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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