PTPN2/1-IN-3

PTPN2/1-IN-3 (compound 4) is a modified, orally active PTPN2/N1 inhibitor based on ABBV-CLS-484 (HY-145923) . PTPN2/1-IN-3 has anti-tumor effects, inhibiting PTPN2 with an IC50 of 9.3 nM and having an oral bioavailability of 93% in mice[1].

Product Specifications

UNSPSC

12352005

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ptpn2-1-in-3.html

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC1=C(N2CC(NS2(=O)=O)=O)C(O)=CC3=C1CCN(CC)CC3

Molecular Formula

C14H18FN3O4S

Molecular Weight

343.37

References & Citations

[1]Zheng J, et al. Synthesis and structure-activity optimization of azepane-containing derivatives as PTPN2/PTPN1 inhibitors. Eur J Med Chem. 2024 Apr 15;270:116390.