Macrophage-activating lipopeptide 2 (TFA)
Macrophage-activating lipopeptide 2 TFA is an agonist of Toll like receptors TLR-2/TLR-6. Macrophage-activating lipopeptide-2 enhances endothelial nitric oxide synthase (eNOS) phosphorylation and endothelial cell release of NO, thereby improving vasodilation. Macrophage-activating lipopeptide-2 enhances endothelial adhesion of white blood cells and improve perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe deficient mice undergoing experimental femoral artery ligation (FAL) [1].
Product Specifications
Product Name Alternative
MALP-2 (TFA)
UNSPSC
12352209
Target
NO Synthase; Toll-like Receptor (TLR)
Type
Peptides
Related Pathways
Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/macrophage-activating-lipopeptide-2-tfa.html
Purity
98.60
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 1.96 mg/mL (ultrasonic; adjust pH to 12 with 1 M NaOH)
Smiles
Molecular Formula
C99H167N19O30S.xC2HF3O2
Molecular Weight
2135.56 (free base)
References & Citations
[1]Troidl K, et al. The Lipopeptide MALP-2 Promotes Collateral Growth. Cells. 2020 Apr 16;9 (4) :997.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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