Macrophage-activating lipopeptide 2 (TFA)

Macrophage-activating lipopeptide 2 TFA is an agonist of Toll like receptors TLR-2/TLR-6. Macrophage-activating lipopeptide-2 enhances endothelial nitric oxide synthase (eNOS) phosphorylation and endothelial cell release of NO, thereby improving vasodilation. Macrophage-activating lipopeptide-2 enhances endothelial adhesion of white blood cells and improve perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe deficient mice undergoing experimental femoral artery ligation (FAL) [1].

Product Specifications

Product Name Alternative

MALP-2 (TFA)

UNSPSC

12352209

Target

NO Synthase; Toll-like Receptor (TLR)

Type

Peptides

Related Pathways

Immunology/Inflammation

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/macrophage-activating-lipopeptide-2-tfa.html

Purity

98.60

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 1.96 mg/mL (ultrasonic; adjust pH to 12 with 1 M NaOH)

Smiles

O=C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@H](C(O)=O)CCCCN)=O)=O)[C@@H](NC([C@H](CO)NC([C@H]([C@@H](C)CC)NC([C@H](CC(N)=O)NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@H](CC(O)=O)NC([C@H](CC(N)=O)NC([C@H](CC(N)=O)NC(CNC([C@@H](N)CSC[C@H](OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC1=CC=CC=C1.O=C(O)C(F)(F)F.[x]