SIRT-IN-4
SIRT-IN-4 is an inhibitor of the NAD+-dependent lysine deacetylase Sirtuin2 (Sirt2) (IC50=0.35 μM) . SIRT-IN-4 is a potent Sirt2 deacetylase inhibitor that reduces cell survival and inhibits the migration of prostate cancer cells. SIRT-IN-4 can be used to study Sirt2 in cell cycle regulation, gene expression regulation, etc[1].
Product Specifications
UNSPSC
12352005
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sirt-in-4.html
Smiles
FC1=CC=CC(CN2CCCC(C2)CC3=NC(C4=CC=C(C=C4)NC(C5=CC=C(C=C5)Cl)=O)=NO3)=C1C
Molecular Formula
C29H28ClFN4O2
Molecular Weight
519.01
References & Citations
[1]Colcerasa A, et al. Structure–Activity Studies of 1, 2, 4-Oxadiazoles for the Inhibition of the NAD+-Dependent Lysine Deacylase Sirtuin 2[J]. Journal of Medicinal Chemistry, 2023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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