Laccase-IN-3

Laccase-IN-3 (Compound 2b) is a laccase inhibitor (IC50 = 1.02= μM) with significant antifungal activity. Laccase-IN-3 shows superior inhibitory effect on Botryosphaeria dothidea (EC50 = 0.17 mg/L) . Laccase-IN-3 effectively blocks the catalytic function of laccase by binding to its active center. Laccase-IN-3 also disrupts pathogen cell membrane integrity and increases ROS[1].

Product Specifications

UNSPSC

12352005

Target

Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/laccase-in-3.html

Solubility

10 mM in DMSO

Smiles

O=C([C@H]1[C@H](C2)C=C[C@H]2C1)NNC3=CC=C(F)C=C3

Molecular Formula

C14H15FN2O

Molecular Weight

246.28

References & Citations

[1]Jin DJ, et al. Design, synthesis, antifungal evaluation and mechanism study of novel norbornene derivatives as potential laccase inhibitors. Pest Manag Sci. 2024 Apr 16.