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EP3 antagonist 3

EP3 antagonist 3 (compound 2) is an orally active, potent and selective EP3 antagonist, with a pKi of 8.3. EP3 antagonist 3 shows excellent pharmacokinetic properties. EP3 antagonist 3 can be used for overactive bladder (OAB) research[1].

Product Specifications

CAS Number

1227827-88-4

UNSPSC

12352005

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ep3-antagonist-3.html

Concentration

10mM

Purity

99.52

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C1OC(C2=CC=C(C3=CC4=C(C=CC=C4)C=C3)NC2=O)(C(C)C)C(N1)=O

Molecular Formula

C21H18N2O4

Molecular Weight

362.38

References & Citations

[1]Jin J, et al. Novel 3-Oxazolidinedione-6-aryl-pyridinones as Potent, Selective, and Orally Active EP3 Receptor Antagonists. ACS Med Chem Lett. 2010 May 14;1 (7) :316-20.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

EP

Available Sizes

Frequently Asked Questions

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