SG2057

SG2057 (DRG16) is a PBD dimer containing a pentyldioxy linkage which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts. SG2057 is a highly active antitumor agent[1].

Product Specifications

CAS Number

[260417-62-7]

Product Name Alternative

DRG16

UNSPSC

12352005

Target

ADC Payload; DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sg2057.html

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N2[C@](CC(C2)=C)([H])C=NC3=CC(OCCCCCOC4=C(OC)C=C5C(N6[C@](CC(C6)=C)([H])C=NC5=C4)=O)=C(OC)C=C13

Molecular Formula

C33H36N4O6

Molecular Weight

584.66

References & Citations

[1]John A Hartley, et al. DNA interstrand cross-linking and in vivo antitumor activity of the extended pyrrolo[2,1-c][1,4]benzodiazepine dimer SG2057. Invest New Drugs. 2012 Jun;30 (3) :950-8.