BRD4/NAMPT-IN-1
Product Specifications
UNSPSC Description
BRD4/NAMPT-IN-1 (Compound A2) shows strong inhibitory effects on NAMPT and BRD4 (IC50=35 nM (NAMPT) and 58 nM (BRD4)). BRD4/NAMPT-IN-1 inhibits the growth and migration of hepatocellular carcinoma cells and promotes apoptosis. BRD4/NAMPT-IN-1 also shows potent anticancer effects in HCCLM3 xenograft mouse model, with no obvious toxic effects[1].
Target Antigen
Epigenetic Reader Domain; NAMPT
Type
Reference compound
Related Pathways
Epigenetics;Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/brd4-nampt-in-1.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC(C=C1)=CC=C1C2=N[C@@H](CC(NCCCNC(/C=C/C3=CN=CC=C3)=O)=O)C4=NN=C(C)N4C5=C2C(C)=C(C)S5
Molecular Weight
588.12
References & Citations
[1]Yin C, et al. Discovery of potent and novel dual NAMPT/BRD4 inhibitors for efficient treatment of hepatocellular carcinoma. Eur J Med Chem. 2024 May 5;271:116444.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161515/BRD4-NAMPT-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161515/BRD4-NAMPT-IN-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
3049218-28-9
Available Sizes
Curated Selection
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