G-5555
Product Specifications
UNSPSC Description
G-5555 is a potent p21-activated kinase 1 (PAK1) inhibitor with Kis of 3.7 nM and 11 nM for PAK1 and PAK2, respectively.
Target Antigen
PAK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/G-5555.html
Purity
99.88
Solubility
DMSO : 25 mg/mL (ultrasonic;warming;heat to 80°C)
Smiles
ClC(C=C(C1=NC(C)=CC=C1)C=C2)=C2C3=CC4=CN=C(NC)N=C4N(C[C@@H]5OC[C@@H](N)CO5)C3=O
Molecular Weight
492.96
References & Citations
[1]Ndubaku CO, et al. Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety. ACS Med Chem Lett. 2015 Oct 31;6(12):1241-6.|[2]Rudolph J, et al. Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window. J Med Chem. 2016 Jun 9;59(11):5520-41.Acta Pharm Sin B. 2020 Apr;10(4):603-614.|Elife. 2017 Mar 13;6:e22207. |Endocr Relat Cancer. 2019 Aug;26(8):699-712. |Exp Hematol. 2023 Sep 21;S0301-472X(23)01701-0.|PLoS One. 2024 Jul 31;19(7):e0305121.|Research Square Preprint. 2021 Apr.|Endocr Relat Cancer. 2019 Aug;26(8):699-712.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-19635/G-5555-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-19635/G-5555-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1648863-90-4
Available Sizes
Curated Selection
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