G-5555
G-5555 is a potent p21-activated kinase 1 (PAK1) inhibitor with Kis of 3.7 nM and 11 nM for PAK1 and PAK2, respectively.
Product Specifications
CAS Number
[1648863-90-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PAK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/G-5555.html
Purity
99.88
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
ClC(C=C(C1=NC(C)=CC=C1)C=C2)=C2C3=CC4=CN=C(NC)N=C4N(C[C@@H]5OC[C@@H](N)CO5)C3=O
Molecular Formula
C25H25ClN6O3
Molecular Weight
492.96
Precautions
H302, H315, H319, H335
References & Citations
[1]Ndubaku CO, et al. Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety. ACS Med Chem Lett. 2015 Oct 31;6 (12) :1241-6.|[2]Rudolph J, et al. Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window. J Med Chem. 2016 Jun 9;59 (11) :5520-41.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAK1; PAK2
Citation 01
Acta Pharm Sin B. 2020 Apr;10 (4) :603-614.|Elife. 2017 Mar 13;6:e22207. |Endocr Relat Cancer. 2019 Aug;26 (8) :699-712.|Exp Hematol. 2023 Nov:127:59-69.e2.|PLoS One. 2024 Jul 31;19 (7) :e0305121.|Research Square Preprint. 2021 Apr.|Endocr Relat Cancer. 2019 Aug;26 (8) :699-712.
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