SB-705498
SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.1.
Product Specifications
CAS Number
501951-42-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/SB-705498.html
Purity
99.72
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
BrC1=CC=CC=C1NC(N[C@@H]2CCN(C3=NC=C(C(F)(F)F)C=C3)C2)=O
Molecular Formula
C17H16BrF3N4O
Molecular Weight
429.23
Precautions
H302, H315, H319, H335
References & Citations
[1]Martin J. Gunthorpe, et al. Characterization of SB-705498, a Potent and Selective Vanilloid Receptor-1 (VR1/TRPV1) Antagonist That Inhibits the Capsaicin-, Acid-, and Heat-Mediated Activation of the Receptor. JPET June 2007 vol. 321 no. 3 1183-1192.|[2]Rami HK, et al. Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development. Bioorg Med Chem Lett. 2006 Jun 15;16 (12) :3287-91.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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