VU0546110

VU0546110 is a selective inhibitor of the sperm-specific potassium channel SLO3, with IC50s of 1.287 μM (SLO3) and 59.80 μM (SLO1) in HEK293 cells, respectively. VU0546110 blocks heterologous SLO3 currents and endogenous K+ currents in human sperm. VU0546110 halts sperm hyperpolarization, induced acrosome reaction, and hyper-activated motility. VU0546110 has contraceptive potential[1].

Product Specifications

CAS Number

[1421523-00-3]

UNSPSC

12352005

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/vu0546110.html

Purity

98.47

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CC1=CC=C(S(=O)(C(C)C)=O)C=C1)N2CCC(CC2)CSC3=CC=C(C=C3)OC

Molecular Formula

C24H31NO4S2

Molecular Weight

461.64

References & Citations

[1]Lyon M, et al. A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function. Proceedings of the National Academy of Sciences of the United States of America. 2023, 120 (4), e2212338120.