Opiorphin

Opiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC50 value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2) . Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission[1][2].

Product Specifications

CAS Number

[864084-88-8]

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Neprilysin

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/opiorphin.html

Purity

98.83

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC[C@H](NC([C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)N)=O)=O)=O)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O

Molecular Formula

C29H48N12O8

Molecular Weight

692.77

Precautions

H302, H315, H319, H335

References & Citations

[1]Wisner A, et, al. Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways. Proc Natl Acad Sci U S A. 2006 Nov 21;103 (47) :17979-84.|[2]Tian XZ, et, al. Effects and underlying mechanisms of human opiorphin on colonic motility and nociception in mice. Peptides. 2009 Jul;30 (7) :1348-54.