Melittin

Melittin is a PLA2 activator, stimulates the activity of the low molecular weight PLA2, while it does not the increase activity of the high molecular weight PLA2[1][2].

Product Specifications

CAS Number

[20449-79-0]

UNSPSC

12352209

Hazard Statement

H301+H311

Target

Phospholipase

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Melittin.html

Purity

99.78

Solubility

H2O : ≥ 50 mg/mL

Smiles

NC(CC[C@@H](C(N)=O)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H]([C@@H](C)CC)NC([C@@H](NC([C@H](CO)NC([C@H]([C@@H](C)CC)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H]1N(CCC1)C([C@H](CC(C)C)NC(CNC([C@H]([C@H](O)C)NC([C@H]([C@H](O)C)NC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H](C)NC(CNC([C@H]([C@@H](C)CC)NC(CN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC2=CNC3=CC=CC=C23)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C131H229N39O31

Molecular Weight

2846.46

Precautions

H301+H311

References & Citations

[1]Steiner MR, et al. Responses of purified phospholipases A2 to phospholipase A2 activating protein (PLAP) and Melittin. Biochim Biophys Acta. 1993 Feb 10;1166 (1) :124-30.|[2]Alonezi S, et al. Metabolomic Profiling of the Effects of Melittin on Cisplatin Resistant and Cisplatin Sensitive Ovarian Cancer Cells Using Mass Spectrometry and Biolog Microarray Technology. Metabolites. 2016 Oct 13;6 (4) . pii: E35.