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SHP2-IN-29

SHP2-IN-29 (Compound 3) is a potent SHP2 inhibitor with an IC50 value of 0.18 μM. SHP2-IN-29 also has inhibitory activity against PTP1B and TCPTP, with IC50 values of 4.27 and 4.74 μM, respectively.

Product Specifications

CAS Number

2130080-86-1

UNSPSC

12352005

Target

Phosphatase; SHP2

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/shp2-in-29.html

Solubility

10 mM in DMSO

Smiles

O=C(O)C1=C(CC/C=C/C=C/CCC)C=C(O)C=C1O

Molecular Formula

C16H20O4

Molecular Weight

276.33

References & Citations

[1]Sun W, et al. Varic acid analogues from fungus as PTP1B inhibitors: Biological evaluation and structure-activity relationships. Bioorg Med Chem Lett. 2017 Aug 1;27 (15) :3382-3385.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

Frequently Asked Questions

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