ICA-105574

ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC50 value of 0.5 +/- 0.1 μM and a Hill slope (n (H) ) of 3.3 +/- 0.2. ICA-105574 can prevent arrhythmias induced by cardiac delayed repolarization. ICA-105574 shortens action potential duration in ventricular myocytes concentration-dependently[1][2].

Product Specifications

CAS Number

[316146-57-3]

UNSPSC

12352005

Hazard Statement

H317, H319, H400

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ica-105574.html

Purity

99.25

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(OC2=CC=CC=C2)C=C1)C3=CC=CC([N+]([O-])=O)=C3

Molecular Formula

C19H14N2O4

Molecular Weight

334.33

Precautions

H317, H319, H400

References & Citations

[1]Gerlach AC, et al. Pharmacological removal of human ether-à-go-go-related gene potassium channel inactivation by 3-nitro-N- (4-phenoxyphenyl) benzamide (ICA-105574) . Mol Pharmacol. 2010;77 (1) :58-68.|[2]Meng, J., et al., (2013) . Compound ICA-105574 prevents arrhythmias induced by cardiac delayed repolarization. European journal of pharmacology, 718 (1-3), 87–97.