GATA4-NKX2-5-IN-1

GATA4-NKX2-5-IN-1 (Compound 3) dose-dependently inhibits the GATA4–NKX2-5 transcriptional synergy with an IC50 of 3 μM. GATA4-NKX2-5-IN-1 exhibits no activity on the protein kinases involved in the regulation of GATA4 phosphorylation, and it modulates the hypertrophic agonist-induced cardiac gene expression[1].

Product Specifications

CAS Number

[544681-96-1]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

IKZF Family

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/gata4-nkx2-5-in-1.html

Concentration

10mM

Purity

99.24

Solubility

DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1=C(C(NC2=CC=C(N(CC)CC)C=C2)=O)C(C3=CC=CC=C3)=NO1

Molecular Formula

C21H23N3O2

Molecular Weight

349.43

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

References & Citations

[1]Välimäki MJ, et al. Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5. J Med Chem. 2017 Sep 28;60 (18) :7781-7798.