Dihydrolipoic Acid

Dihydrolipoic Acid (DHLA) is an excellent antioxidant capable of scavenging almost any oxygen-centered radical[1]. Dihydrolipoic acid exhibits anti-inflammatory properties in various diseases. Dihydrolipoic Acid exerts a preventive effect via ERK/Nrf2/HO-1/ROS/NLRP3 pathway in LPS-induced sickness behavior rats. Dihydrolipoic Acid can be used for the reaserch of depression[2].

Product Specifications

CAS Number

[462-20-4]

Product Name Alternative

DHLA

UNSPSC

12352211

Hazard Statement

H302, H315, H317, H318, H411

Target

Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dihydrolipoic-acid.html

Purity

99.95

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC(CCCCC(CCS)S)=O

Molecular Formula

C8H16O2S2

Molecular Weight

208.34

Precautions

H302, H315, H317, H318, H411

References & Citations

[1]Romina Castañeda-Arriaga, et al. Lipoic acid and dihydrolipoic acid. A comprehensive theoretical study of their antioxidant activity supported by available experimental kinetic data. J Chem Inf Model. 2014 Jun 23;54 (6) :1642-52.|[2]Hetao Bian, et al. Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/NLRP3 signaling in rat. J Neuroinflammation. 2020 May 25;17 (1) :166.