C-Myb (Acetyl Lys471) rabbit pAb

Domain: Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression. function: Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. PTM: Phosphorylated by NLK on multiple sites, which induces proteasomal degradation. PTM: Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation. similarity: Contains 3 HTH myb-type DNA-binding domains. subunit: Binds MYBBP1A. Interacts with HIPK2, MAF and NLK.