Propargyl-PEG2-methylamine

Propargyl-PEG2-methylamine (Propargyl-PEG2-NHMe) is a PEG derivative containing a propargyl group and methylamine group. Propargyl-PEG2-methylamine is an PROTAC linker used in the synthesis of PROTACs. Propargyl-PEG2-methylamine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups[1].

Product Specifications

CAS Number

[1835759-76-6]

Product Name Alternative

Propargyl-PEG2-NHMe

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/propargyl-peg2-methylamine.html

Smiles

C#CCOCCOCCNC

Molecular Formula

C8H15NO2

Molecular Weight

157.21

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61 (2) :453-461.