NNC 26-9100

NNC 26-9100 is a selective somatostatin sst4 receptor full agonist (Ki: 6 nM, EC50: 2 nM) . NNC 26-9100 decreases total soluble Aβ42, increases brain neprilysin activity and improves learning[1][2].

Product Specifications

CAS Number

[199522-35-5]

UNSPSC

12352005

Target

Amyloid-β; Somatostatin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nnc-26-9100.html

Purity

99.3

Solubility

10 mM in DMSO

Smiles

S=C(NCCCC1=CN=CN1)NCCCN(C2=NC=C(Br)C=C2)CC3=CC=C(Cl)C(Cl)=C3

Molecular Formula

C22H25BrCl2N6S

Molecular Weight

556.35

References & Citations

[1]Michael Ankersen, et al. Discovery of a Novel Non-Peptide Somatostatin Agonist with SST4 Selectivity. J. Am. Chem. Soc. 1998, 120, 7, 1368-1373.|[2]Sandoval KE, et al. Somatostatin receptor subtype-4 agonist NNC 26-9100 mitigates the effect of soluble Aβ (42) oligomers via a metalloproteinase-dependent mechanism. Brain Res. 2013 Jul 3;1520:145-56.