NNC 26-9100
NNC 26-9100 is a selective somatostatin sst4 receptor full agonist (Ki: 6 nM, EC50: 2 nM) . NNC 26-9100 decreases total soluble Aβ42, increases brain neprilysin activity and improves learning[1][2].
Product Specifications
CAS Number
199522-35-5
UNSPSC
12352005
Target
Amyloid-β; Somatostatin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nnc-26-9100.html
Purity
99.3
Solubility
10 mM in DMSO
Smiles
S=C(NCCCC1=CN=CN1)NCCCN(C2=NC=C(Br)C=C2)CC3=CC=C(Cl)C(Cl)=C3
Molecular Formula
C22H25BrCl2N6S
Molecular Weight
556.35
References & Citations
[1]Michael Ankersen, et al. Discovery of a Novel Non-Peptide Somatostatin Agonist with SST4 Selectivity. J. Am. Chem. Soc. 1998, 120, 7, 1368-1373.|[2]Sandoval KE, et al. Somatostatin receptor subtype-4 agonist NNC 26-9100 mitigates the effect of soluble Aβ (42) oligomers via a metalloproteinase-dependent mechanism. Brain Res. 2013 Jul 3;1520:145-56.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LC421117 20 µg
TMEM120B (NM_001080825) Human Over-expression Lysate
Sign In for Pricing
View Details 
LC402105 20 µg
IRAKM (IRAK3) (NM_007199) Human Over-expression Lysate
Sign In for Pricing
View Details 
E-EL-R0883-01 24 Tests
Rat SHBG (Sex Hormone Binding Globulin) ELISA Kit
Sign In for Pricing
View Details E-EL-R0883-02 48 Tests
Rat SHBG (Sex Hormone Binding Globulin) ELISA Kit
Sign In for Pricing
View Details E-EL-R0883-03 96 Tests
Rat SHBG (Sex Hormone Binding Globulin) ELISA Kit
Sign In for Pricing
View Details