1,3-PBIT (dihydrobromide)
1,3-PBIT is a potent inhibitor of iNOS with a Ki of 47 nM compared to Ki values for eNOS and nNOS are 9 and 0.25 μM, respectively, for the purified human enzymes. Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability.
Product Specifications
CAS Number
200716-66-1
UNSPSC
12352005
Target
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/1-3-pbit-dihydrobromide.html
Smiles
NC(SCCC1=CC(CCSC(N)=N)=CC=C1)=N.Br.Br
Molecular Formula
C12H20Br2N4S2
Molecular Weight
444.25
References & Citations
[1]Garvey, et al. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. J. Biol. Chem. 269 (43), 26669-26676 (1994) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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