Amikacin (sulfate)

Amikacin sulfate (BAY 41-6551 sulfate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin sulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin sulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin sulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria[1][2].

Product Specifications

CAS Number

[149022-22-0]

Product Name Alternative

BAY 41-6551 (sulfate)

UNSPSC

12352211

Hazard Statement

H317

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/amikacin-sulfate-1.html

Purity

99.91

Solubility

H2O : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O[C@@H]1[C@H]([C@@H](C[C@H](N)[C@H]1O[C@@]([C@@H]([C@@H](O)[C@@H]2O)O)([H])O[C@@H]2CN)NC([C@@H](O)CCN)=O)O[C@@]([C@@H]([C@@H](N)[C@@H]3O)O)([H])O[C@@H]3CO.O=[S](O)(O)=O.[9/5]

Molecular Formula

C22H43N5O13.9/5H2O4S

Molecular Weight

762.14

Precautions

H317

References & Citations

[1]Edson, R.S. and C.L. Terrell, The aminoglycosides. Mayo Clin Proc, 1999. 74 (5) : p. 519-28.|[2]Ristuccia AM, et al. An overview of amikacin. Ther Drug Monit. 1985;7 (1) :12-25.|[3]Siân R Kitcher, et al. ORC-13661 Protects Sensory Hair Cells From Aminoglycoside and Cisplatin Ototoxicity. JCI Insight. 2019 Aug 8;4 (15) :e126764.