LDN-209929 (dihydrochloride)

LDN-209929 dihydrochloride is a potent and selective haspin kinase inhibitor (IC50=55 nM) with180-fold selectivity verses DYRK2 (IC50=9.9 μM) . LDN-209929 is a optimized analogue of LDN-192960 (HY-13455) [2].

Product Specifications

CAS Number

[1784281-97-5]

UNSPSC

12352005

Target

DYRK; Haspin Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ldn-209929-dihydrochloride.html

Purity

98.33

Solubility

DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NCCCSC1=C(C=C(Cl)C=C2)C2=NC3=CC=C(OC)C=C31.[H]Cl.[H]Cl

Molecular Formula

C17H19Cl3N2OS

Molecular Weight

405.77

References & Citations

[1]Gregory D Cuny, et al. Structure-activity Relationship Study of Acridine Analogs as Haspin and DYRK2 Kinase Inhibitors. Bioorg Med Chem Lett|[2]Katrin Kestav, et al. Structure, Roles and Inhibitors of a Mitotic Protein Kinase Haspin. Curr Med Chem. 2017;24 (21) :2276-2293.