Pasireotide (L-aspartate salt)
Product Specifications
UNSPSC Description
Pasireotide (SOM230) L-aspartate salt, a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/[1][2].
Target Antigen
Somatostatin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein;Neuronal Signaling
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/pasireotide-l-aspartate-salt.html
Purity
98.0
Solubility
DMSO : 1 mg/mL (ultrasonic)
Smiles
N[C@@H](CC(O)=O)C(O)=O.NCCCC[C@@H](C(N[C@H]1CC2=CC=C(C=C2)OCC3=CC=CC=C3)=O)NC([C@H](NC([C@H](C4=CC=CC=C4)NC([C@H]5N(C([C@H](CC6=CC=CC=C6)NC1=O)=O)C[C@H](OC(NCCN)=O)C5)=O)=O)CC7=CNC8=C7C=CC=C8)=O
Molecular Weight
1180.31
References & Citations
[1]Lewis I, et, al. A novel somatostatin mimic with broad somatotropin release inhibitory factor receptor binding and superior therapeutic potential. J Med Chem. 2003 Jun 5;46(12):2334-44.|[2]Quinn TJ, et, al. Pasireotide (SOM230) is effective for the treatment of pancreatic neuroendocrine tumors (PNETs) in a multiple endocrine neoplasia type 1 (MEN1) conditional knockout mouse model. Surgery. 2012 Dec;152(6):1068-77.|[3]Imhof AK, et, al. Differential antiinflammatory and antinociceptive effects of the somatostatin analogs octreotide and pasireotide in a mouse model of immune-mediated arthritis. Arthritis Rheum. 2011 Aug;63(8):2352-62.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-79136/Pasireotide-L-aspartate-salt-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-79136/Pasireotide-L-aspartate-salt-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
396091-77-3
Available Sizes
Curated Selection
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