Trehalose 6,6′-dimycolate

Trehalose 6,6'-dimycolate (Cord Factor) is trehalose 6,6'-dimycolate, a cell wall glycolipid of Mycobacterium tuberculosis, which can be used to simulate inflammation and granuloma induced by Mycobacterium tuberculosis (MTB) form. Trehalose 6,6′-dimycolate also protects Mycobacterium tuberculosis from macrophage-mediated killing, inhibits efficient antigen presentation, and reduces the development of protective T cell responses[1][2].

Product Specifications

CAS Number

[61512-20-7]

Product Name Alternative

Cord Factor

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Biochemical Assay Reagents

Type

Biochemical Assay Reagents

Related Pathways

Others

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/trehalose-6-6-dimycolate.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

[Trehalose6,6?dimycolate]

Precautions

H302, H315, H319, H335

References & Citations

[1]Hwang SA, et al. Mycobacterial trehalose 6,6'-dimycolate induced vascular occlusion is accompanied by subendothelial inflammation. Tuberculosis (Edinb) . 2019 May;116S:S118-S122.|[2]Welsh KJ, et al. Trehalose 6,6'-dimycolate--a coat to regulate tuberculosis immunopathogenesis. Tuberculosis (Edinb) . 2013 Dec;93 Suppl:S3-9.