KRpep-2d
KRpep-2d is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research[1].
Product Specifications
CAS Number
[2098181-84-9]
UNSPSC
12352209
Target
Ras
Type
Peptides
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/krpep-2d.html
Purity
95.09
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
O=C1N2C(CCC2)(C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC3=CC=C(O)C=C3)C(=O)N[C@@]([C@H](CC)C)(C(=O)N[C@@H](CO)C(=O)N[C@@H](CC4=CC=C(O)C=C4)C(=O)N[C@@H](CC(O)=O)C(=O)N5[C@](C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CSSC[C@@H]1NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(=N)N)NC(C)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)(CCC5)[H])[H])[H]
Molecular Formula
C108H182N44O25S2
Molecular Weight
2561.02
References & Citations
[1]Niida A, et al. Investigation of the structural requirements of K-Ras (G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging. Bioorg Med Chem Lett. 2017 Jun 15;27 (12) :2757-2761.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
K-Ras
Available Sizes
Curated Selection
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