Bfl-1-IN-3
Bfl-1-IN-3 (Compound 56) is a selective, competitive inhibitor for Bfl-1 on BID binding site with Ki of 105 nM. Bfl-1-IN-3 inhibits the proliferation of cell pfeiffer and MV4-11, with IC50 of 6.92 μM and 12.6 μM. Bfl-1-IN-3 induces apoptosis in pfeiffer cells. Bfl-1-IN-3 overcomes Venetoclax resistance at the cellular level, and shows synergistically enhanced anti-tumor activity with Venetoclax[1].
Product Specifications
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bfl-1-in-3.html
Smiles
ClC1=CC(CC)=C(C2=C(CN3CCN(C4=CC(OC5=CC(C=CN6)=C6N=C5)=C(C(O)=O)C=C4)CC3)CCC7=CC(NC(C=C)=O)=CC=C27)C=C1
Molecular Formula
C40H38ClN5O4
Molecular Weight
688.21
References & Citations
[1]Lou J, et al., Discovery of a Covalent Inhibitor That Overcame Resistance to Venetoclax in AML Cells Overexpressing BFL-1. J Med Chem. 2024 Jun 24.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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